Ontology highlight
ABSTRACT:
SUBMITTER: Nawa N
PROVIDER: S-EPMC6663065 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Nawa Nobutoshi N Hirata Katsuya K Kawatani Keiji K Nambara Toshihiko T Omori Sayaka S Banno Kimihiko K Kokubu Chikara C Takeda Junji J Nishimura Ken K Ohtaka Manami M Nakanishi Mahito M Okuzaki Daisuke D Taniguchi Hidetoshi H Arahori Hitomi H Wada Kazuko K Kitabatake Yasuji Y Ozono Keiichi K
PloS one 20190729 7
Chromosome abnormalities induces profound alterations in gene expression, leading to various disease phenotypes. Recent studies on yeast and mammalian cells have demonstrated that aneuploidy exerts detrimental effects on organismal growth and development, regardless of the karyotype, suggesting that aneuploidy-associated stress plays an important role in disease pathogenesis. However, whether and how this effect alters cellular homeostasis and long-term features of human disease are not fully un ...[more]