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Inter-individual differences in human brain structure and morphology link to variation in demographics and behavior.

ABSTRACT: We perform a comprehensive integrative analysis of multiple structural MR-based brain features and find for the first-time strong evidence relating inter-individual brain structural variations to a wide range of demographic and behavioral variates across a large cohort of young healthy human volunteers. Our analyses reveal that a robust 'positive-negative' spectrum of behavioral and demographic variates, recently associated to covariation in brain function, can already be identified using only structural features, highlighting the importance of careful integration of structural features in any analysis of inter-individual differences in functional connectivity and downstream associations with behavioral/demographic variates.

SUBMITTER: Llera A

PROVIDER: S-EPMC6663467 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Inter-individual differences in human brain structure and morphology link to variation in demographics and behavior.

Llera Alberto A Wolfers Thomas T Mulders Peter P Beckmann Christian F CF

eLife 20190703

We perform a comprehensive integrative analysis of multiple structural MR-based brain features and find for the first-time strong evidence relating inter-individual brain structural variations to a wide range of demographic and behavioral variates across a large cohort of young healthy human volunteers. Our analyses reveal that a robust 'positive-negative' spectrum of behavioral and demographic variates, recently associated to covariation in brain function, can already be identifie ...[more]

PMID: 31268418

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