Preparation of Radiopaque Drug-Eluting Beads for Transcatheter Chemoembolization.

ABSTRACT:

Purpose

To develop a simple method to produce radiopaque drug-eluting microspheres (drug-eluting beads [DEBs]) that could be incorporated into the current clinical transcatheter arterial chemoembolization workflow and evaluate their performance in vitro and in vivo.

Materials and methods

An ethiodized oil (Lipiodol; Guerbet, Villepinte, France) and ethanol solution was added to a lyophilized 100-300 µm bead before loading with doxorubicin. These radiopaque drug-eluting beads (DEBs; Biocompatibles UK Ltd, Farnham, United Kingdom) were evaluated in vitro for x-ray attenuation, composition, size, drug loading and elution, and correlation between attenuation and doxorubicin concentration. In vivo conspicuity was evaluated in a VX2 tumor model.

Results

Lipiodol was loaded

SUBMITTER: Johnson CG 

PROVIDER: S-EPMC6663477 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature