Ontology highlight
ABSTRACT:
SUBMITTER: Darzi ER
PROVIDER: S-EPMC6663605 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Darzi Evan R ER Barber Joyann S JS Garg Neil K NK
Angewandte Chemie (International ed. in English) 20190530 28
We report a modular synthetic strategy for accessing heteroatom-containing polycyclic aromatic hydrocarbons (PAHs). Our approach relies on the controlled generation of transient heterocyclic alkynes and arynes. The strained intermediates undergo in situ trapping with readily accessible oxadiazinones. Four sequential pericyclic reactions occur, namely two Diels-Alder/retro-Diels-Alder sequences, which can be performed in a stepwise or one-pot fashion to assemble four new carbon-carbon (C-C) bonds ...[more]