Ontology highlight
ABSTRACT:
SUBMITTER: Yam M
PROVIDER: S-EPMC6664195 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Yam Michelle M Engel Abbi L AL Wang Yekai Y Zhu Siyan S Hauer Allison A Zhang Rui R Lohner Daniel D Huang Jiancheng J Dinterman Marlee M Zhao Chen C Chao Jennifer R JR Du Jianhai J
The Journal of biological chemistry 20190519 26
The retinal pigment epithelium (RPE) is a monolayer of pigmented cells between the choroid and the retina. RPE dysfunction underlies many retinal degenerative diseases, including age-related macular degeneration, the leading cause of age-related blindness. To perform its various functions in nutrient transport, phagocytosis of the outer segment, and cytokine secretion, the RPE relies on an active energy metabolism. We previously reported that human RPE cells prefer proline as a nutrient and tran ...[more]