Dataset Information

Predicting the risk of pulmonary tuberculosis based on the neutrophil-to-lymphocyte ratio at TB screening in HIV-infected individuals.

ABSTRACT:

Background

The neutrophil to lymphocyte ratio (NL ratio) has been reported to be a predictive biomarker of tuberculosis (TB). We assessed the association between the NL ratio and the incidence of active TB cases within 1?year after TB screening among HIV-infected individuals in Thailand.

Methods

A day care center that supports HIV-infected individuals in northernmost Thailand performed TB screening and follow-up visits. We compared the baseline characteristics between the TB screening positive group and the TB screening negative group. The threshold value of NL ratio was determined by cubic-spline curves and NL ratios were categorized as high or low NL ratio. We assessed the association between NL ratio and progression to active TB within 1-year using the Cox-proportional hazard model.

Results

Of the 1064 HIV-infected individuals who screened negative for TB at baseline, 5.6% (N?=?60) eventually developed TB and 26 died after TB diagnosis. A high NL ratio was associated with a higher risk of TB (adjusted hazard ratio (aHR) 2.19, 95% CI: 1.23-3.90), after adjusting for age, sex, ethnicity, CD4 counts, and other risk factors. A high NL ratio in HIV-infected individuals with normal chest X-ray predicted TB development risk. In particular, a high NL ratio with TB symptoms could predict the highest risk of TB development (aHR 2.58, 95%CI: 1.07-6.23).

Conclusions

Our results showed that high NL ratio increased the risk of TB. NL ratio combined with TB symptoms could increase the accuracy of TB screening among HIV-infected individuals.

SUBMITTER: Miyahara R

PROVIDER: S-EPMC6664723 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Publications

Predicting the risk of pulmonary tuberculosis based on the neutrophil-to-lymphocyte ratio at TB screening in HIV-infected individuals.

Miyahara Reiko R Piyaworawong Surachai S Naranbhai Vivek V Prachamat Prarit P Kriengwatanapong Prapimporn P Tsuchiya Naho N Wongyai Jiraporn J Bupachat Surasit S Yamada Norio N Summanapan Surin S Mahasirimongkol Surakameth S Yanai Hideki H

BMC infectious diseases 20190729 1

<h4>Background</h4>The neutrophil to lymphocyte ratio (NL ratio) has been reported to be a predictive biomarker of tuberculosis (TB). We assessed the association between the NL ratio and the incidence of active TB cases within 1 year after TB screening among HIV-infected individuals in Thailand.<h4>Methods</h4>A day care center that supports HIV-infected individuals in northernmost Thailand performed TB screening and follow-up visits. We compared the baseline characteristics between the TB scree ...[more]

PMID: 31357936

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Dataset Information

Predicting the risk of pulmonary tuberculosis based on the neutrophil-to-lymphocyte ratio at TB screening in HIV-infected individuals.

Background

Methods

Results

Conclusions

Publications

Predicting the risk of pulmonary tuberculosis based on the neutrophil-to-lymphocyte ratio at TB screening in HIV-infected individuals.

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