Dataset Information
Predicting acute radiation induced xerostomia in head and neck Cancer using MR and CT Radiomics of parotid and submandibular glands.
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ABSTRACT: Purpose
To analyze baseline CT/MR-based image features of salivary glands to predict radiation-induced xerostomia 3-months after head-and-neck cancer (HNC) radiotherapy.Methods
A retrospective analysis was performed on 266 HNC patients who were treated using radiotherapy at our institution between 2009 and 2018. CT and T1 post-contrast MR images along with NCI-CTCAE xerostomia grade (3-month follow-up) were prospectively collected at our institution. CT and MR images were registered on which parotid/submandibular glands were contoured. Image features were extracted for ipsilateral/contralateral parotid and submandibular glands relative to the location of the primary tumor. Dose-volume-histogram (DVH) parameters were also acquired. Features were pre-selected based on Spearman correlation before modelling by examining the correlation with xerostomia (p?ResultsAmong extracted features, 7 CT, 5 MR, and 2 DVH features were selected. The internal cohort (n?=?216) ROC-AUC values for DVH, CT, MR, and Clinical+DVH?+?CT?+?MR features were 0.73?±?0.01, 0.69?±?0.01, 0.70?±?0.01, and 0.79?±?0.01, respectively. The validation cohort (n?=?50) ROC-AUC values for DVH, CT, MR, and Clinical+DVH?+?CT?+?MR features were 0.63, 0.57, 0.66, and 0.68, respectively. The DVH-ROC was not significantly different than the CT-ROC (p?=?0.8) or MR-ROC (p?=?0.4). However, the CT?+?MR-ROC was significantly different than the CT-ROC (p?=?0.03), but not the Clinical+DVH?+?CT?+?MR model (p?=?0.5).Conclusion
Our results suggest that baseline CT and MR image features may reflect baseline salivary gland function and potential risk for radiation injury. The integration of baseline image features into prediction models has the potential to improve xerostomia risk stratification with the ultimate goal of truly personalized HNC radiotherapy.
SUBMITTER: Sheikh K
PROVIDER: S-EPMC6664784 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Publications
Predicting acute radiation induced xerostomia in head and neck Cancer using MR and CT Radiomics of parotid and submandibular glands.
Radiation oncology (London, England) 20190729 1
<h4>Purpose</h4>To analyze baseline CT/MR-based image features of salivary glands to predict radiation-induced xerostomia 3-months after head-and-neck cancer (HNC) radiotherapy.<h4>Methods</h4>A retrospective analysis was performed on 266 HNC patients who were treated using radiotherapy at our institution between 2009 and 2018. CT and T1 post-contrast MR images along with NCI-CTCAE xerostomia grade (3-month follow-up) were prospectively collected at our institution. CT and MR images were registe ...[more]
