Dataset Information

Membrane-delimited coupling of TRPV1 and mGluR5 on presynaptic terminals of nociceptive neurons.

ABSTRACT: Transient receptor potential vanilloid subtype 1 (TRPV1) and metabotropic glutamate receptor 5 (mGluR5) located on peripheral sensory terminals have been shown to play critical roles in the transduction and modulation of pain sensation. To date, however, very little is known regarding the significance of functional expression of mGluR5 and TRPV1 on the central terminals of sensory neurons in the dorsal horn of the spinal cord. Here we show that TRPV1 on central presynaptic terminals is coupled to mGluR5 in a membrane-delimited manner, thereby contributing to the modulation of nociceptive synaptic transmission in the substantia gelatinosa neurons of the spinal cord. Further, our results demonstrate that TRPV1 is involved in the pain behaviors induced by spinal mGluR5 activation, and diacylglycerol produced by the activation of mGluR5 mediates functional coupling of mGluR5 and TRPV1 on the presynaptic terminals. Thus, mGluR5-TRPV1 coupling on the central presynaptic terminals of nociceptive neurons may be an important mechanism underlying central sensitization under pathological pain conditions.

SUBMITTER: Kim YH

PROVIDER: S-EPMC6664976 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature

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Membrane-delimited coupling of TRPV1 and mGluR5 on presynaptic terminals of nociceptive neurons.

Kim Yong Ho YH Park Chul-Kyu CK Back Seung Keun SK Lee C Justin CJ Hwang Se Jin SJ Bae Yong Chul YC Na Heung Sik HS Kim Joong Soo JS Jung Sung Jun SJ Oh Seog Bae SB

The Journal of neuroscience : the official journal of the Society for Neuroscience 20090801 32

Transient receptor potential vanilloid subtype 1 (TRPV1) and metabotropic glutamate receptor 5 (mGluR5) located on peripheral sensory terminals have been shown to play critical roles in the transduction and modulation of pain sensation. To date, however, very little is known regarding the significance of functional expression of mGluR5 and TRPV1 on the central terminals of sensory neurons in the dorsal horn of the spinal cord. Here we show that TRPV1 on central presynaptic terminals is coupled t ...[more]

PMID: 19675234

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Dataset Information

Membrane-delimited coupling of TRPV1 and mGluR5 on presynaptic terminals of nociceptive neurons.

Publications

Membrane-delimited coupling of TRPV1 and mGluR5 on presynaptic terminals of nociceptive neurons.

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