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Intensive follow-up strategies after radical surgery for nonmetastatic colorectal cancer: A systematic review and meta-analysis of randomized controlled trials.

ABSTRACT: BACKGROUND:Intensive follow-up after surgery for colorectal cancers is common in clinical practice, but evidence of a survival benefit is limited. OBJECTIVE:To conduct a systematic review and meta-analysis on the effects of follow-up strategies for nonmetastatic colorectal cancer. DATA SOURCES:We searched Medline, Embase, and CENTRAL databases through May 30, 2018. STUDY SELECTION:We included randomized clinical trials evaluating intensive follow-up versus less follow-up in patients with nonmetastatic colorectal cancer. INTERVENTIONS:Intensive follow-up. MAIN OUTCOMES MEASURES:Overall survival. RESULTS:The analyses included 17 trials with a total of 8039 patients. Compared with less follow-up, intensive follow-up significantly improved overall survival in patients with nonmetastatic colorectal cancer after radical surgery (HR 0.85, 95% CI 0.74-0.97, P = 0.01; I2 = 30%; high quality). Subgroup analyses showed that differences between intensive-frequency and intensive-test follow-up (P = 0.04) and between short interval and long interval of follow-up (P = 0.02) in favor of the former one. LIMITATIONS:Clinical heterogeneity of interventions. CONCLUSIONS:For patients with nonmetastatic colorectal cancer after curative resection, intensive follow-up strategy was associated with an improvement in overall survival compared with less follow-up strategy. Intensive-frequency follow-up strategy was associated with a greater reduction in mortality compared with intensive-test follow-up strategy.

SUBMITTER: Zhao Y

PROVIDER: S-EPMC6667274 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Intensive follow-up strategies after radical surgery for nonmetastatic colorectal cancer: A systematic review and meta-analysis of randomized controlled trials.

Zhao Yaqin Y Yi Cheng C Zhang Yu Y Fang Fang F Faramand Andrew A

PloS one 20190730 7

<h4>Background</h4>Intensive follow-up after surgery for colorectal cancers is common in clinical practice, but evidence of a survival benefit is limited.<h4>Objective</h4>To conduct a systematic review and meta-analysis on the effects of follow-up strategies for nonmetastatic colorectal cancer.<h4>Data sources</h4>We searched Medline, Embase, and CENTRAL databases through May 30, 2018.<h4>Study selection</h4>We included randomized clinical trials evaluating intensive follow-up versus less follo ...[more]

PMID: 31361784

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Project description:BACKGROUND: Controversy exists with regard to the impact that the different components of diagnosis delay may have on the degree of invasion and prognosis in patients with colorectal cancer. The follow-up strategies after treatment also vary considerably. The aims of this study are: a) to determine if the symptoms-to-diagnosis interval and the treatment delay modify the survival of patients with colorectal cancer, and b) to determine if different follow-up strategies are associated with a higher survival rate. METHODS/DESIGN: Multi-centre study with prospective follow-up in five regions in Spain (Galicia, Balearic Islands, Catalonia, Aragón and Valencia) during the period 2010-2012. Incident cases are included with anatomopathological confirmation of colorectal cancer (International Classification of Diseases 9th revision codes 153-154) that formed a part of a previous study (n = 953).At the time of diagnosis, each patient was given a structured interview. Their clinical records will be reviewed during the follow-up period in order to obtain information on the explorations and tests carried out after treatment, and the progress of these patients.Symptoms-to-diagnosis interval is defined as the time calculated from the diagnosis of cancer and the first symptoms attributed to cancer. Treatment delay is defined as the time elapsed between diagnosis and treatment. In non-metastatic patients treated with curative intention, information will be obtained during the follow-up period on consultations performed in the digestive, surgery and oncology departments, as well as the endoscopies, tumour markers and imaging procedures carried out.Local recurrence, development of metastases in the follow-up, appearance of a new tumour and mortality will be included as outcome variables.Actuarial survival analysis with Kaplan-Meier curves, Cox regression and competitive risk survival analysis will be performed. DISCUSSION: This study will make it possible to verify if the different components of delay have an impact on survival rate in colon cancer and rectal cancer. In consequence, this multi-centre study will be able to detect the variability present in the follow-up of patients with colorectal cancer, and if this variability modifies the prognosis. Ideally, this study could determine which follow-up strategies are associated with a better prognosis in colorectal cancer.

Dataset Information

Intensive follow-up strategies after radical surgery for nonmetastatic colorectal cancer: A systematic review and meta-analysis of randomized controlled trials.

Publications

Intensive follow-up strategies after radical surgery for nonmetastatic colorectal cancer: A systematic review and meta-analysis of randomized controlled trials.

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