Ontology highlight
ABSTRACT:
SUBMITTER: Vadnais ML
PROVIDER: S-EPMC6667352 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Current opinion in structural biology 20160610
Cow antibodies are unusual in having an exceptionally long third complementarity determining region of the heavy chain (CDR H3). These CDR H3s have a multitude of cysteines and form a distinct domain characterized by a β-ribbon 'stalk' and disulfide bonded 'knob'. Cows appear to utilize somatic hypermutation of a single VDJ rearrangement to produce an astounding variety of distinct CDR H3 sequences with different disulfide bonding patterns within the knob. Thus, cows may be unique amongst verteb ...[more]