Bos taurus ultralong CDR H3 antibodies.
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ABSTRACT:
SUBMITTER: Vadnais ML
PROVIDER: S-EPMC6667352 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Publications
Bos taurus ultralong CDR H3 antibodies.
Vadnais Melissa L ML Smider Vaughn V VV
Current opinion in structural biology 20160610
Cow antibodies are unusual in having an exceptionally long third complementarity determining region of the heavy chain (CDR H3). These CDR H3s have a multitude of cysteines and form a distinct domain characterized by a β-ribbon 'stalk' and disulfide bonded 'knob'. Cows appear to utilize somatic hypermutation of a single VDJ rearrangement to produce an astounding variety of distinct CDR H3 sequences with different disulfide bonding patterns within the knob. Thus, cows may be unique amongst verteb ...[more]
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