Ontology highlight
ABSTRACT:
SUBMITTER: Bhardwaj V
PROVIDER: S-EPMC6667505 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Bhardwaj Vivek V Semplicio Giuseppe G Erdogdu Niyazi Umut NU Manke Thomas T Akhtar Asifa A
Nature communications 20190730 1
The position, shape and number of transcription start sites (TSS) are critical determinants of gene regulation. Most methods developed to detect TSSs and study promoter usage are, however, of limited use in studies that demand quantification of expression changes between two or more groups. In this study, we combine high-resolution detection of transcription start sites and differential expression analysis using a simplified TSS quantification protocol, MAPCap (Multiplexed Affinity Purification ...[more]