Bacterial Translocation and Host Immune Activation in Chronic Hepatitis C Infection.
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ABSTRACT:
SUBMITTER: Moon MS
PROVIDER: S-EPMC6667717 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Publications
Bacterial Translocation and Host Immune Activation in Chronic Hepatitis C Infection.
Moon Mi Sun MS Quinn Gabriella G Townsend Elizabeth C EC Ali Rabab O RO Zhang Grace Y GY Bradshaw Alyson A Hill Kareen K Guan Hannah H Hamilton Destanee D Kleiner David E DE Koh Christopher C Heller Theo T
Open forum infectious diseases 20190701 7
Hepatitis C virus (HCV) infects 71 million individuals, and barriers to treatment remain. Bacterial translocation is a complication of chronic HCV infection, and this study evaluated circulating microbial components including lipopolysaccharide, peptidoglycan, and β-D-glucan in addition to their pattern recognition receptors and degree of hepatic macrophage uptake. The findings suggest that regulation of serum peptidoglycan and β-D-glucan differs from that of lipopolysaccharide. Additionally, ma ...[more]
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