WONOEP appraisal: Network concept from an imaging perspective.
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ABSTRACT:
SUBMITTER: Wykes RC
PROVIDER: S-EPMC6667743 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Publications
WONOEP appraisal: Network concept from an imaging perspective.
Wykes Robert C RC Khoo Hui Ming HM Caciagli Lorenzo L Blumenfeld Hal H Golshani Peyman P Kapur Jaideep J Stern John M JM Bernasconi Andrea A Dedeurwaerdere Stefanie S Bernasconi Neda N
Epilepsia 20190609 7
Neuroimaging techniques applied to a variety of organisms-from zebrafish, to rodents to humans-can offer valuable insights into neuronal network properties and their dysfunction in epilepsy. A wide range of imaging methods used to monitor neuronal circuits and networks during evoked seizures in animal models and advances in functional magnetic resonance imaging (fMRI) applied to patients with epilepsy were discussed during the XIV Workshop on Neurobiology of Epilepsy (XIV WONOEP) organized in 20 ...[more]
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Project description:Modern radiation therapy is delivered with great precision, in part by relying on high-resolution multidimensional anatomic imaging to define targets in space and time. The development of quantitative imaging (QI) modalities capable of monitoring biologic parameters could provide deeper insight into tumor biology and facilitate more personalized clinical decision-making. The Quantitative Imaging Network (QIN) was established by the National Cancer Institute to advance and validate these QI modalities in the context of oncology clinical trials. In particular, the QIN has significant interest in the application of QI to widen the therapeutic window of radiation therapy. QI modalities have great promise in radiation oncology and will help address significant clinical needs, including finer prognostication, more specific target delineation, reduction of normal tissue toxicity, identification of radioresistant disease, and clearer interpretation of treatment response. Patient-specific QI is being incorporated into radiation treatment design in ways such as dose escalation and adaptive replanning, with the intent of improving outcomes while lessening treatment morbidities. This review discusses the current vision of the QIN, current areas of investigation, and how the QIN hopes to enhance the integration of QI into the practice of radiation oncology.
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Project description:IntroductionPhase-contrast imaging (PCI) is a novel technology that can visualise variations in X-ray refraction (phase contrast) in addition to differences in X-ray attenuation (absorption contrast). Compared to radiography using conventional methods (i.e. absorption-based imaging), PCI techniques can potentially produce images with higher contrast-to-noise ratio and superior spatial resolution at the same or lower radiation doses. This has led PCI to be explored for implementation in medical imaging. While interest in this research field is increasing, the whole body of PCI research in medical imaging has been under-investigated. This paper provides an overview of PCI literature and then focusses on evaluating its development within the scope of medical imaging.MethodsBibliographic data between 1995 and 2018 were used to visualise collaboration networks between countries, institutions and authors. Social network analysis techniques were implemented to measure these networks in terms of centrality and cohesion. These techniques also assisted in the exploration of underlying research paradigms of clinical X-ray PCI investigations.ResultsForty-one countries, 592 institutions and 2073 authors contributed 796 investigations towards clinical PCI research. The most influential contributors and network collaboration characteristics were identified. Italy was the most influential country, with the European Synchrotron Radiation Facility being the most influential institution. At an author level, F. Pfeiffer was found to be the most influential researcher. Among various PCI techniques, grating interferometry was the most investigated, while computed tomography was the most frequently examined modality.ConclusionsBy gaining an understanding of collaborations and trends within clinical X-ray PCI research, the links between existing collaborators were identified, which can aid future collaborations between emerging and established collaborators. Moreover, exploring the paradigm of past investigations can shape future research - well-researched PCI techniques may be studied to bring X-ray PCI closer to clinical implementation, or the potential of seldom-investigated techniques may be explored.
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