Ontology highlight
ABSTRACT:
SUBMITTER: Garaeva AA
PROVIDER: S-EPMC6668440 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Garaeva Alisa A AA Guskov Albert A Slotboom Dirk J DJ Paulino Cristina C
Nature communications 20190731 1
The human Alanine Serine Cysteine Transporter 2 (ASCT2) is a neutral amino acid exchanger that belongs to the solute carrier family 1 (SLC1A). SLC1A structures have revealed an elevator-type mechanism, in which the substrate is translocated across the cell membrane by a large displacement of the transport domain, whereas a small movement of hairpin 2 (HP2) gates the extracellular access to the substrate-binding site. However, it has remained unclear how substrate binding and release is gated on ...[more]