Ontology highlight
ABSTRACT:
SUBMITTER: Khalil DN
PROVIDER: S-EPMC6668692 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Khalil Danny N DN Suek Nathan N Campesato Luis Felipe LF Budhu Sadna S Redmond David D Samstein Robert M RM Krishna Chirag C Panageas Katherine S KS Capanu Marinela M Houghton Sean S Hirschhorn Daniel D Zappasodi Roberta R Giese Rachel R Gasmi Billel B Schneider Michael M Gupta Aditi A Harding James J JJ Moral John Alec JA Balachandran Vinod P VP Wolchok Jedd D JD Merghoub Taha T
The Journal of clinical investigation 20190722 8
Irreversible T cell exhaustion limits the efficacy of programmed cell death 1 (PD-1) blockade. We observed that dual CD40-TLR4 stimulation within a single tumor restored PD-1 sensitivity and that this regimen triggered a systemic tumor-specific CD8+ T cell response. This approach effectively treated established tumors in diverse syngeneic cancer models, and the systemic effect was dependent on the injected tumor, indicating that treated tumors were converted into necessary components of this the ...[more]