Ontology highlight
ABSTRACT:
SUBMITTER: Yao J
PROVIDER: S-EPMC6668698 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Yao Jiayi J Wu Xiuju X Zhang Daoqin D Wang Lumin L Zhang Li L Reynolds Eric X EX Hernandez Carlos C Boström Kristina I KI Yao Yucheng Y
The Journal of clinical investigation 20190624 8
Lumen integrity in vascularization requires fully differentiated endothelial cells (ECs). Here, we report that endothelial-mesenchymal transitions (EndMTs) emerged in ECs of cerebral arteriovenous malformation (AVMs) and caused disruption of the lumen or lumen disorder. We show that excessive Sry-box 2 (Sox2) signaling was responsible for the EndMTs in cerebral AVMs. EC-specific suppression of Sox2 normalized endothelial differentiation and lumen formation and improved the cerebral AVMs. Epigene ...[more]