Ontology highlight
ABSTRACT:
SUBMITTER: Fernandez A
PROVIDER: S-EPMC6668992 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Fernandez Alejandra A Meechan Daniel W DW Karpinski Beverly A BA Paronett Elizabeth M EM Bryan Corey A CA Rutz Hanna L HL Radin Eric A EA Lubin Noah N Bonner Erin R ER Popratiloff Anastas A Rothblat Lawrence A LA Maynard Thomas M TM LaMantia Anthony-Samuel AS
Neuron 20190509 6
Under-connectivity between cerebral cortical association areas may underlie cognitive deficits in neurodevelopmental disorders, including the 22q11.2 deletion syndrome (22q11DS). Using the LgDel 22q11DS mouse model, we assessed cellular, molecular, and developmental origins of under-connectivity and its consequences for cognitive function. Diminished 22q11 gene dosage reduces long-distance projections, limits axon and dendrite growth, and disrupts mitochondrial and synaptic integrity in layer 2/ ...[more]