Ontology highlight
ABSTRACT:
SUBMITTER: Oster C
PROVIDER: S-EPMC6669007 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Öster Carl C Hendriks Kitty K Kopec Wojciech W Chevelkov Veniamin V Shi Chaowei C Michl Dagmar D Lange Sascha S Sun Han H de Groot Bert L BL Lange Adam A
Science advances 20190731 7
Ion conduction through potassium channels is a fundamental process of life. On the basis of crystallographic data, it was originally proposed that potassium ions and water molecules are transported through the selectivity filter in an alternating arrangement, suggesting a "water-mediated" knock-on mechanism. Later on, this view was challenged by results from molecular dynamics simulations that revealed a "direct" knock-on mechanism where ions are in direct contact. Using solid-state nuclear magn ...[more]