Enrichment of extracellular vesicles with lipid nanoprobe functionalized nanostructured silica.
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ABSTRACT:
SUBMITTER: Wan Y
PROVIDER: S-EPMC6669184 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Publications
Enrichment of extracellular vesicles with lipid nanoprobe functionalized nanostructured silica.
Wan Yuan Y Maurer Mackenzie M He Hong-Zhang HZ Xia Yi-Qiu YQ Hao Si-Jie SJ Zhang Wen-Long WL Yee Nelson S NS Zheng Si-Yang SY
Lab on a chip 20190701 14
Nanoscale extracellular vesicles (nEVs) have recently demonstrated potential value in cancer diagnostics and treatment monitoring, but translation has been limited by technical challenges in nEV isolation. Thus, we have developed a one-step nEV isolation platform that utilizes nEV size-matched silica nanostructures and a surface-conjugated lipid nanoprobe with an integrated microfluidic mixer. The reported platform has 28.8% capture efficiency from pancreatic cancer plasma and can sufficiently e ...[more]
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