Ontology highlight
ABSTRACT:
SUBMITTER: Miles LA
PROVIDER: S-EPMC6669322 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Miles Luke A LA Hermans Stefan J SJ Crespi Gabriela A N GAN Gooi Jonathan H JH Doughty Larissa L Nero Tracy L TL Markulić Jasmina J Ebneth Andreas A Wroblowski Berthold B Oehlrich Daniel D Trabanco Andrés A AA Rives Marie-Laure ML Royaux Ines I Hancock Nancy C NC Parker Michael W MW
iScience 20190719
Polymorphism in the microglial receptor CD33 gene has been linked to late-onset Alzheimer disease (AD), and reduced expression of the CD33 sialic acid-binding domain confers protection. Thus, CD33 inhibition might be an effective therapy against disease progression. Progress toward discovery of selective CD33 inhibitors has been hampered by the absence of an atomic resolution structure. We report here the crystal structures of CD33 alone and bound to a subtype-selective sialic acid mimetic calle ...[more]