Ontology highlight
ABSTRACT:
SUBMITTER: Cui J
PROVIDER: S-EPMC6669377 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Cui Jing J Diogo Dorothee D Stahl Eli A EA Canhao Helena H Mariette Xavier X Greenberg Jeffrey D JD Okada Yukinori Y Pappas Dimitrios A DA Fulton Robert S RS Tak Paul P PP Nurmohamed Michael T MT Lee Annette A Larson David E DE Kurreeman Fina F Deluca Tracie L TL O'Laughlin Michelle M Fronick Catrina C CC Fulton Lucinda L LL Mardis Elaine R ER van der Horst-Bruinsma Irene E IE Wolbink Gert-Jan GJ Gregersen Peter K PK Kremer Joel M JM Crusius J Bart A JB de Vries Niek N Huizinga Tom W J TW Fonseca João Eurico JE Miceli-Richard Corinne C Karlson Elizabeth W EW Coenen Marieke J H MJ Barton Anne A Plenge Robert M RM Raychaudhuri Soumya S
Arthritis & rheumatology (Hoboken, N.J.) 20170401 4
<h4>Objective</h4>In many rheumatoid arthritis (RA) patients, disease is controlled with anti-tumor necrosis factor (anti-TNF) biologic therapies. However, in a significant number of patients, the disease fails to respond to anti-TNF therapy. We undertook the present study to examine the hypothesis that rare and low-frequency genetic variants might influence response to anti-TNF treatment.<h4>Methods</h4>We sequenced the coding region of 750 genes in 1,094 RA patients of European ancestry who we ...[more]