Ontology highlight
ABSTRACT:
SUBMITTER: Spiliopoulou A
PROVIDER: S-EPMC6669378 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Spiliopoulou Athina A Colombo Marco M Plant Darren D Nair Nisha N Cui Jing J Coenen Marieke Jh MJ Ikari Katsunori K Yamanaka Hisashi H Saevarsdottir Saedis S Padyukov Leonid L Bridges S Louis SL Kimberly Robert P RP Okada Yukinori Y van Riel Piet L Cm PLC Wolbink Gertjan G van der Horst-Bruinsma Irene E IE de Vries Niek N Tak Paul P PP Ohmura Koichiro K Canhão Helena H Guchelaar Henk-Jan HJ Huizinga Tom Wj TW Criswell Lindsey A LA Raychaudhuri Soumya S Weinblatt Michael E ME Wilson Anthony G AG Mariette Xavier X Isaacs John D JD Morgan Ann W AW Pitzalis Costantino C Barton Anne A McKeigue Paul P
Annals of the rheumatic diseases 20190429 8
<h4>Objectives</h4>We sought to investigate whether genetic effects on response to TNF inhibitors (TNFi) in rheumatoid arthritis (RA) could be localised by considering known genetic susceptibility loci for relevant traits and to evaluate the usefulness of these genetic loci for stratifying drug response.<h4>Methods</h4>We studied the relation of TNFi response, quantified by change in swollen joint counts ( Δ SJC) and erythrocyte sedimentation rate ( Δ ESR) with locus-specific scores constructed ...[more]