Heparan Sulfate Proteoglycans and Viral Attachment: True Receptors or Adaptation Bias?
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ABSTRACT:
SUBMITTER: Cagno V
PROVIDER: S-EPMC6669472 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Publications
Heparan Sulfate Proteoglycans and Viral Attachment: True Receptors or Adaptation Bias?
Cagno Valeria V Tseligka Eirini D ED Jones Samuel T ST Tapparel Caroline C
Viruses 20190701 7
Heparan sulfate proteoglycans (HSPG) are composed of unbranched, negatively charged heparan sulfate (HS) polysaccharides attached to a variety of cell surface or extracellular matrix proteins. Widely expressed, they mediate many biological activities, including angiogenesis, blood coagulation, developmental processes, and cell homeostasis. HSPG are highly sulfated and broadly used by a range of pathogens, especially viruses, to attach to the cell surface. ...[more]
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