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Cytotoxic Sesquiterpenoid Quinones and Quinols, and an 11-Membered Heterocycle, Kauamide, from the Hawaiian Marine Sponge Dactylospongia elegans.


ABSTRACT: Several known sesquiterpenoid quinones and quinols (1-9), and kauamide (10), a new polyketide-peptide containing an 11-membered heterocycle, were isolated from the extracts of the Hawaiian marine sponge Dactylospongia elegans. The planar structure of 10 was determined from spectroscopic analyses, and its relative and absolute configurations were established from density functional theory (DFT) calculations of the GIAO NMR shielding tensors, and advanced Marfey's analysis of the N-MeLeu residue, respectively. Compounds 1 and 3 showed moderate inhibition of ?-secretase 1 (BACE1), whereas 1-9 exhibited moderate to potent inhibition of growth of human glioma (U251) cells. Compounds 1-2 and 4-7 were also active against human pancreatic carcinoma (Panc-1) cells.

SUBMITTER: Neupane RP 

PROVIDER: S-EPMC6669564 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Cytotoxic Sesquiterpenoid Quinones and Quinols, and an 11-Membered Heterocycle, Kauamide, from the Hawaiian Marine Sponge <i>Dactylospongia elegans</i>.

Neupane Ram P RP   Parrish Stephen M SM   Neupane Jayanti Bhandari JB   Yoshida Wesley Y WY   Yip M L Richard MLR   Turkson James J   Harper Mary Kay MK   Head John D JD   Williams Philip G PG  

Marine drugs 20190719 7


Several known sesquiterpenoid quinones and quinols (<b>1</b>-<b>9</b>), and kauamide (<b>10</b>), a new polyketide-peptide containing an 11-membered heterocycle, were isolated from the extracts of the Hawaiian marine sponge <i>Dactylospongia</i> <i>elegans</i>. The planar structure of <b>10</b> was determined from spectroscopic analyses, and its relative and absolute configurations were established from density functional theory (DFT) calculations of the GIAO NMR shielding tensors, and advanced  ...[more]

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