Dataset Information

High serum uric acid level is a mortality risk factor in peritoneal dialysis patients: a retrospective cohort study.

ABSTRACT:

Background

The results remain controversial with regards to the impact of serum uric acid on clinical outcomes from peritoneal dialysis population. The aim of our study was to investigate the influence of serum uric acid levels on mortality in peritoneal dialysis patients.

Methods

Data on 9405 peritoneal dialysis patients from the Zhejiang Renal Data system were retrospectively analyzed. All demographic and laboratory data were recorded at baseline. The study cohort was divided into quintiles according to baseline uric acid level (mg/dL): Q1 (ResultsMean serum uric acid was 7.07?±?1.25?mg/dL. During a median follow-up of 29.4 (range, 3.0 to 115.4) months, 1226 (13.0%) patients died, of which 515 (5.5%) died of cardiovascular events. The Kaplan-Meier survival curves showed that patients in the middle uric acid quintile (Q3: 6.68-7.27) exhibited the highest patient and cardiovascular survival rates (log-rank test P?P?=?0.009; Q5: HR, 1.482, 95% CI, 1.187 to 1.849, P?=?0.001), but not with cardiovascular mortality. The adverse effect of higher uric acid level (?7.28?mg/dL) on all-cause mortality was more prominent in groups such as male, hypoalbuminemia, normal weight, non-diabetes mellitus at baseline rather than in their counterparts respectively.

Conclusions

A higher uric acid level was an independent risk factor for all-cause mortality in peritoneal dialysis patients.

SUBMITTER: Xiang S

PROVIDER: S-EPMC6670192 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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High serum uric acid level is a mortality risk factor in peritoneal dialysis patients: a retrospective cohort study.

Xiang Shilong S Zhang Xiaohui X Xie Xishao X Wang Junni J Zhou Qin Q Chen Zhimin Z Wang Yaomin Y Liu Guangjun G Han Fei F Chen Jianghua J

Nutrition & metabolism 20190801

<h4>Background</h4>The results remain controversial with regards to the impact of serum uric acid on clinical outcomes from peritoneal dialysis population. The aim of our study was to investigate the influence of serum uric acid levels on mortality in peritoneal dialysis patients.<h4>Methods</h4>Data on 9405 peritoneal dialysis patients from the Zhejiang Renal Data system were retrospectively analyzed. All demographic and laboratory data were recorded at baseline. The study cohort was divided in ...[more]

PMID: 31388342

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Project description:ObjectivesTo analyse the relationship between serum uric acid (SUA), all-cause and cardiovascular (CV) mortality in peritoneal dialysis (PD) patients to inform clinical practice and future research.DesignA systematic review of observational studies.Data sourcesPubMed, Embase, Web of Science, the Cochrane Library, China National Knowledge Infrastructure (CNKI), SinoMed, Chinese Science and Technology Journal Database (VIP) and Wan Fang databases were searched from their inception to January 2021 for cohort and case-control studies reporting SUA and mortality in patients with PD.MethodsThe Newcastle-Ottawa Quality Assessment Scale was used to appraise quality of cohort and case-control studies. Effect estimates were presented as HRs with 95% CIs in a meta-analysis using STATA V.16.0. Data not suitable for pooling were synthesised qualitatively.ResultsFourteen cohort studies with 24 022 patients were included. No case-control studies were identified. For prospective cohort studies, pooled results for the highest SUA category were significantly greater than the lowest for all-cause (one study; 1278participants; HR 1.79; 95% CI 1.17 to 2.75) and CV mortality (one study; 1278 participants; HR 2.63; 1.62-4.27). An increase of 1 mg/dL in SUA level was associated with a 16% increased risk of all-cause mortality (one study; 1278 participants; HR 1.16; 1.03-1.32) and 34% increased CV mortality risk (one study; 1278 participants; HR 1.34; 1.16-1.55). For retrospective cohort studies, the highest SUA category did not demonstrate an elevated all-cause (five studies; 4570 participants; HR 1.09; 0.70-1.70) or CV mortality (three studies; 3748 participants; HR 1.00; 0.44-2.31) compared with the lowest SUA category. Additionally, there was no increase in all-cause (eight studies; 11 541 participants; HR 0.94; 0.88-1.02) or CV mortality (three studies; 7427 participants; HR 0.90; 0.76-1.06) for every 1 mg/dL increase in SUA level.ConclusionsResults of prospective and retrospective cohort studies were inconsistent. Consequently, prospective, multicentre, long-term follow-up studies are required to confirm the relationship between SUA and mortality in patients with PD.

Dataset Information

High serum uric acid level is a mortality risk factor in peritoneal dialysis patients: a retrospective cohort study.

Background

Methods

Conclusions

Publications

High serum uric acid level is a mortality risk factor in peritoneal dialysis patients: a retrospective cohort study.

Similar Datasets

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