Ontology highlight
ABSTRACT:
SUBMITTER: Khalaj Z
PROVIDER: S-EPMC6670283 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences 20190724
Cytochrome P450 2D6 (CYP2D6) is an important drug-metabolizing enzyme involved in the pharmacokinetic metabolism of drugs. <i>CYP2D6</i> gene is highly polymorphic, and the combination of its different alleles yields different phenotypes including extensive metabolizer (EM), intermediate metabolizer (IM), poor metabolizer (PM), and ultrarapid metabolizer (UM). Genotyping of the important alleles for this gene in different ethnicities is of particular importance for assessing the efficacy of vari ...[more]