Dataset Information

Chronic exposure to cadmium is associated with a marked reduction in glomerular filtration rate.

ABSTRACT:

Background

Urinary 20-hydroxyeicosatetraenoic acid (20-HETE) has been associated with hypertension in women with elevated urinary cadmium (Cd) excretion rates. The present study investigates the urinary Cd and 20-HETE levels in relation to the estimated glomerular filtration rate (eGFR) and albumin excretion in men and women.

Methods

A population-based, cross-sectional study, which included 225 women and 84 men aged 33-55?years, was conducted in a rural area known to be polluted with Cd.

Results

In all subjects, lower eGFR values were associated with higher urinary Cd excretion (P?=?0.030), and tubulopathy markers N-acetyl-?-d-glucosaminidase (P?2 lower than that in the hypertensive (P?=?0.009) and normotensive subjects (P?ConclusionsTubulopathy is a determinant of albumin excretion in women, while 20-HETE and SBP are determinants of urinary albumin excretion in men. Associations of chronic exposure to Cd with marked eGFR decline and renal tubular injury seen in both Cd-exposed men and women add to mounting research data that links Cd to the risk of developing chronic kidney disease.

SUBMITTER: Satarug S

PROVIDER: S-EPMC6671389 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Publications

Chronic exposure to cadmium is associated with a marked reduction in glomerular filtration rate.

Satarug Soisungwan S Boonprasert Kanyarat K Gobe Glenda C GC Ruenweerayut Ronnatrai R Johnson David W DW Na-Bangchang Kesara K Vesey David A DA

Clinical kidney journal 20181121 4

<h4>Background</h4>Urinary 20-hydroxyeicosatetraenoic acid (20-HETE) has been associated with hypertension in women with elevated urinary cadmium (Cd) excretion rates. The present study investigates the urinary Cd and 20-HETE levels in relation to the estimated glomerular filtration rate (eGFR) and albumin excretion in men and women.<h4>Methods</h4>A population-based, cross-sectional study, which included 225 women and 84 men aged 33-55 years, was conducted in a rural area known to be polluted w ...[more]

PMID: 31384436

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Dataset Information

Chronic exposure to cadmium is associated with a marked reduction in glomerular filtration rate.

Background

Methods

Results

Publications

Chronic exposure to cadmium is associated with a marked reduction in glomerular filtration rate.

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