Ontology highlight
ABSTRACT:
SUBMITTER: Seruggia D
PROVIDER: S-EPMC6671628 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Seruggia Davide D Oti Martin M Tripathi Pratibha P Canver Matthew C MC LeBlanc Lucy L Di Giammartino Dafne C DC Bullen Michael J MJ Nefzger Christian M CM Sun Yu Bo Yang YBY Farouni Rick R Polo Jose M JM Pinello Luca L Apostolou Effie E Kim Jonghwan J Orkin Stuart H SH Das Partha Pratim PP
Molecular cell 20190417 6
Self-renewal and pluripotency of the embryonic stem cell (ESC) state are established and maintained by multiple regulatory networks that comprise transcription factors and epigenetic regulators. While much has been learned regarding transcription factors, the function of epigenetic regulators in these networks is less well defined. We conducted a CRISPR-Cas9-mediated loss-of-function genetic screen that identified two epigenetic regulators, TAF5L and TAF6L, components or co-activators of the GNA ...[more]