Rivaroxaban, a specific FXa inhibitor, improved endothelium-dependent relaxation of aortic segments in diabetic mice.
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ABSTRACT:
SUBMITTER: Pham PT
PROVIDER: S-EPMC6672013 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
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Rivaroxaban, a specific FXa inhibitor, improved endothelium-dependent relaxation of aortic segments in diabetic mice.
Pham Phuong Tran PT Fukuda Daiju D Yagi Shusuke S Kusunose Kenya K Yamada Hirotsugu H Soeki Takeshi T Shimabukuro Michio M Sata Masataka M
Scientific reports 20190801 1
Activated factor X (FXa) plays a central role in the coagulation cascade, while it also mediates vascular function through activation of protease-activated receptors (PARs). Here, we examined whether inhibition of FXa by rivaroxaban, a direct FXa inhibitor, attenuates endothelial dysfunction in streptozotocin (STZ)-induced diabetic mice. Induction of diabetes increased the expression of a major FXa receptor, PAR2, in the aorta (P < 0.05). Administration of rivaroxaban (10 mg/kg/day) to diabetic ...[more]
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