Ontology highlight
ABSTRACT:
SUBMITTER: Goding CR
PROVIDER: S-EPMC6672050 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Genes & development 20190523 15-16
All transcription factors are equal, but some are more equal than others. In the 25 yr since the gene encoding the microphthalmia-associated transcription factor (MITF) was first isolated, MITF has emerged as a key coordinator of many aspects of melanocyte and melanoma biology. Like all transcription factors, MITF binds to specific DNA sequences and up-regulates or down-regulates its target genes. What marks MITF as being remarkable among its peers is the sheer range of biological processes that ...[more]