Ontology highlight
ABSTRACT:
SUBMITTER: Mark KA
PROVIDER: S-EPMC6672707 | biostudies-literature | 2007 Jun
REPOSITORIES: biostudies-literature
Mark Karla A KA Quinton Maria S MS Russek Shelley J SJ Yamamoto Bryan K BK
The Journal of neuroscience : the official journal of the Society for Neuroscience 20070601 25
The vesicular glutamate (GLU) transporter (VGLUT1) is a critical component of glutamatergic neurons that regulates GLU release. Despite the likely role of GLU release in drug abuse pathology, there is no information that links VGLUT1 with drugs of abuse. This study provides the first evidence that methamphetamine (METH) alters the dynamic regulation of striatal VGLUT1 function and expression through a polysynaptic pathway. METH increases cortical VGLUT1 mRNA, striatal VGLUT1 protein in subcellul ...[more]