Ontology highlight
ABSTRACT:
SUBMITTER: Wright AG
PROVIDER: S-EPMC6673613 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Wright Amanda G AG Demyanenko Galina P GP Powell Ashton A Schachner Melitta M Enriquez-Barreto Lilian L Tran Tracy S TS Polleux Franck F Maness Patricia F PF
The Journal of neuroscience : the official journal of the Society for Neuroscience 20071201 50
We report a cooperation between the neural adhesion molecule close homolog of L1 (CHL1) and the semaphorin 3A (Sema3A) receptor, neuropilin 1 (Npn1), important for establishment of area-specific thalamocortical projections. CHL1 deletion in mice selectively disrupted the projection of somatosensory thalamic axons from the ventrobasal (VB) nuclei, causing them to shift caudally and target the visual cortex. At the ventral telencephalon, an intermediate target with graded Sema3A expression, VB axo ...[more]