Ontology highlight
ABSTRACT:
SUBMITTER: Johnston MJ
PROVIDER: S-EPMC6673710 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Johnston Michael J MJ Nikolic Ana A Ninkovic Nicoletta N Guilhamon Paul P Cavalli Florence M G FMG Seaman Steven S Zemp Franz J FJ Lee John J Abdelkareem Aly A Ellestad Katrina K Murison Alex A Kushida Michelle M MM Coutinho Fiona J FJ Ma Yussanne Y Mungall Andrew J AJ Moore Richard R Marra Marco A MA Taylor Michael D MD Dirks Peter B PB Pugh Trevor J TJ Morrissy Sorana S St Croix Bradley B Mahoney Douglas J DJ Lupien Mathieu M Gallo Marco M
Genome research 20190627 8
We investigated the role of 3D genome architecture in instructing functional properties of glioblastoma stem cells (GSCs) by generating sub-5-kb resolution 3D genome maps by in situ Hi-C. Contact maps at sub-5-kb resolution allow identification of individual DNA loops, domain organization, and large-scale genome compartmentalization. We observed differences in looping architectures among GSCs from different patients, suggesting that 3D genome architecture is a further layer of inter-patient hete ...[more]