Dataset Information

Allelic variation in RGS4 impacts functional and structural connectivity in the human brain.

ABSTRACT: Regulator of G-protein signaling 4 (RGS4) modulates postsynaptic signal transduction by affecting the kinetics of G alpha-GTP binding. Linkage, association, and postmortem studies have implicated the gene encoding RGS4 (RGS4) as a schizophrenia susceptibility factor. Using a multimodal neuroimaging approach, we demonstrate that genetic variation in RGS4 is associated with functional activation and connectivity during working memory in the absence of overt behavioral differences, with regional gray and white matter volume and with gray matter structural connectivity in healthy human subjects. Specifically, variation at one RGS4 single nucleotide polymorphism that has been associated previously with psychosis (rs951436) impacts frontoparietal and frontotemporal blood oxygenation level-dependent response and network coupling during working memory and results in regionally specific reductions in gray and white matter structural volume in individuals carrying the A allele. These findings suggest mechanisms in brain for the association of RGS4 with risk for psychiatric illness.

SUBMITTER: Buckholtz JW

PROVIDER: S-EPMC6673752 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature

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Allelic variation in RGS4 impacts functional and structural connectivity in the human brain.

Buckholtz Joshua W JW Meyer-Lindenberg Andreas A Honea Robyn A RA Straub Richard E RE Pezawas Lukas L Egan Michael F MF Vakkalanka Radhakrishna R Kolachana Bhaskar B Verchinski Beth A BA Sust Steven S Mattay Venkata S VS Weinberger Daniel R DR Callicott Joseph H JH

The Journal of neuroscience : the official journal of the Society for Neuroscience 20070201 7

Regulator of G-protein signaling 4 (RGS4) modulates postsynaptic signal transduction by affecting the kinetics of G alpha-GTP binding. Linkage, association, and postmortem studies have implicated the gene encoding RGS4 (RGS4) as a schizophrenia susceptibility factor. Using a multimodal neuroimaging approach, we demonstrate that genetic variation in RGS4 is associated with functional activation and connectivity during working memory in the absence of overt behavioral differences, with regional gr ...[more]

PMID: 17301167

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Dataset Information

Allelic variation in RGS4 impacts functional and structural connectivity in the human brain.

Publications

Allelic variation in RGS4 impacts functional and structural connectivity in the human brain.

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