Ontology highlight
ABSTRACT:
SUBMITTER: Grueter BA
PROVIDER: S-EPMC6674094 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
Grueter Brad A BA Gosnell Heather B HB Olsen Christopher M CM Schramm-Sapyta Nicole L NL Nekrasova Tanya T Landreth Gary E GE Winder Danny G DG
The Journal of neuroscience : the official journal of the Society for Neuroscience 20060301 12
The bed nucleus of the stria terminalis (BNST) is a key component of the CNS stress and reward circuit. Synaptic plasticity in this region could in part underlie the persistent behavioral alterations in generalized anxiety and addiction. Group I metabotropic glutamate receptors (mGluRs) have been implicated in stress, addiction, and synaptic plasticity, but their roles in the BNST are unknown. We find that activation of group I mGluRs in the dorsal BNST induces depression of excitatory synaptic ...[more]