Ontology highlight
ABSTRACT:
SUBMITTER: Ren YA
PROVIDER: S-EPMC6675546 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Ren Yi Athena YA Monkkonen Teresa T Lewis Michael T MT Bernard Daniel J DJ Christian Helen C HC Jorgez Carolina J CJ Moore Joshua A JA Landua John D JD Chin Haelee M HM Chen Weiqin W Singh Swarnima S Kim Ik Sun IS Zhang Xiang Hf XH Xia Yan Y Phillips Kevin J KJ MacKay Harry H Waterland Robert A RA Ljungberg M Cecilia MC Saha Pradip K PK Hartig Sean M SM Coll Tatiana Fiordelisio TF Richards JoAnne S JS
JCI insight 20190702
Hormones produced by the anterior pituitary gland regulate an array of important physiological functions, but pituitary hormone disorders are not fully understood. Herein we report that genetically-engineered mice with deletion of the hedgehog signaling receptor Patched1 by S100a4 promoter-driven Cre recombinase (S100a4-Cre;Ptch1fl/fl mutants) exhibit adult-onset hypogonadotropic hypogonadism and multiple pituitary hormone disorders. During the transition from puberty to adult, S100a4-Cre;Ptch1f ...[more]