Quasi-Resonance Fluorine-19 Signal Amplification by Reversible Exchange.

ABSTRACT: We report on an extension of the quasi-resonance (QUASR) pulse sequence used for signal amplification by reversible exchange (SABRE), showing that we may target distantly J-coupled ¹⁹F-spins. Polarization transfer from the parahydrogen-derived hydrides to the ¹⁹F nucleus is accomplished via weak five-bond J-couplings using a shaped QUASR radio frequency pulse at a 0.05 T magnetic field. The net result is the direct generation of hyperpolarized ¹⁹F z-magnetization, derived from the parahydrogen singlet order. An accumulation of ¹⁹F polarization on the free ligand is achieved with subsequent repetition of this pulse sequence. The hyperpolarized ¹⁹F signal exhibits clear dependence on the pulse length, irradiation fre

SUBMITTER: Ariyasingha NM 

PROVIDER: S-EPMC6675627 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature