Ontology highlight
ABSTRACT:
SUBMITTER: Seidel J
PROVIDER: S-EPMC6675640 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Seidel Jeremy J Miao Yupeng Y Porterfield William W Cai Wenlong W Zhu Xuejun X Kim Seong-Jong SJ Hu Fanghao F Bhattarai-Kline Santi S Min Wei W Zhang Wenjun W
Chemical communications (Cambridge, England) 20190801 63
Small-molecule natural products have been an essential source of pharmaceuticals to treat human diseases, but very little is known about their behavior inside dynamic, live human cells. Here, we demonstrate the first structure-activity-distribution relationship (SADR) study of complex natural products, the anti-cancer antimycin-type depsipeptides, using the emerging bioorthogonal Stimulated Raman Scattering (SRS) Microscopy. Our results show that the intracellular enrichment and distribution of ...[more]