Dataset Information

Uric Acid Has Different Effects on Spontaneous Brain Activities of Males and Females: A Cross-Sectional Resting-State Functional MR Imaging Study.

ABSTRACT:

Objective

To explore the relationship among serum uric acid (SUA) levels in different states of disease, human cognition, and spontaneous brain activities by resting-state functional MRI (rs-fMRI).

Methods

We prospectively recruited 100 subjects (age 58 ± 11 years, 55 females) who underwent fasting blood sampling, cognitive tests and rs-fMRI scans. The subjects were divided into two groups by sex and each sex group was further stratified into three subgroups according to SUA level in different states of disease. The amplitude of low-frequency fluctuation (ALFF) method was applied to assess spontaneous brain activity among groups. Pearson's correlation analysis was used to investigate the relationships between the mean ALFF values (mALFF) and cognitive tests.

Results

A total of 97 patients completed the study protocol successfully. Significant differences in age, education level, number connection test (NCT), and word fluency were observed among the three subgroups in males (all P < 0.05). Results of group-by-sex interaction were distributed in bilateral pallidum and putamen [voxel P-value < 0.001, cluster P-value < 0.05, Gaussian random field (GRF)-corrected]. The tendency of the SUA effect on mALFF was different in males and females, particularly in corresponding High SUA subgroups (that is pre-hyperuricemia, both P < 0.001). Among the male subjects, mALFF values of the bilateral pallidum and putamen negatively correlated with attention/executive function.

Conclusion

Our results suggest that elevated SUA levels have different effects on spontaneous brain activities and cognitive function in males and females. Males with pre-hyperuricemia and hyperuricemia are more susceptible to changes in spontaneous brain activities and lower neuropsychological assessment scores, particularly in word fluency tests and NCT, compared to females.

SUBMITTER: Lin L

PROVIDER: S-EPMC6676594 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Publications

Uric Acid Has Different Effects on Spontaneous Brain Activities of Males and Females: A Cross-Sectional Resting-State Functional MR Imaging Study.

Lin Li L Zheng Li Juan LJ Joseph Schoepf U U Varga-Szemes Akos A Savage Rock H RH Wang Yun Fei YF Zhang Han H Zhang Xin Yuan XY Lu Guang Ming GM Zhang Long Jiang LJ

Frontiers in neuroscience 20190726

<h4>Objective</h4>To explore the relationship among serum uric acid (SUA) levels in different states of disease, human cognition, and spontaneous brain activities by resting-state functional MRI (rs-fMRI).<h4>Methods</h4>We prospectively recruited 100 subjects (age 58 ± 11 years, 55 females) who underwent fasting blood sampling, cognitive tests and rs-fMRI scans. The subjects were divided into two groups by sex and each sex group was further stratified into three subgroups according to SUA level ...[more]

PMID: 31404153

Similar Datasets

Project description:BackgroundRecent functional MRI (fMRI) studies have demonstrated that there is an intrinsically organized default mode network (DMN) in the resting brain, primarily made up of the posterior cingulate cortex (PCC) and the medial prefrontal cortex (MPFC). Several previous studies have found that the DMN is minimally disturbed during different resting-state conditions with limited cognitive demand. However, this conclusion was drawn from the visual inspection of the functional connectivity patterns within the DMN and no statistical comparison was performed.Methodology/principal findingsFour resting-state fMRI sessions were acquired: 1) eyes-closed (EC) (used to generate the DMN mask); 2) EC; 3) eyes-open with no fixation (EO); and 4) eyes-open with a fixation (EO-F). The 2-4 sessions were counterbalanced across participants (n = 20, 10 males). We examined the statistical differences in both functional connectivity and regional amplitude of low frequency fluctuation (ALFF) within the DMN among the 2-4 resting-state conditions (i.e., EC, EO, and EO-F). Although the connectivity patterns of the DMN were visually similar across these three different conditions, we observed significantly higher functional connectivity and ALFF in both the EO and the EO-F conditions as compared to the EC condition. In addition, the first and second resting EC conditions showed significant differences within the DMN, suggesting an order effect on the DMN activity.Conclusions/significanceOur findings of the higher DMN connectivity and regional spontaneous activities in the resting state with the eyes open suggest that the participants might have more non-specific or non-goal-directed visual information gathering and evaluation, and mind wandering or daydreaming during the resting state with the eyes open as compared to that with the eyes closed, thus providing insights into the understanding of unconstrained mental activity within the DMN. Our results also suggest that it should be cautious when choosing the type of a resting condition and designating the order of the resting condition in multiple scanning sessions in experimental design.

Dataset Information

Uric Acid Has Different Effects on Spontaneous Brain Activities of Males and Females: A Cross-Sectional Resting-State Functional MR Imaging Study.

Objective

Methods

Results

Conclusion

Publications

Uric Acid Has Different Effects on Spontaneous Brain Activities of Males and Females: A Cross-Sectional Resting-State Functional MR Imaging Study.

Similar Datasets

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