Identification of significant gene and pathways involved in HBV-related hepatocellular carcinoma by bioinformatics analysis.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is a common malignant tumor affecting the digestive system and causes serious financial burden worldwide. Hepatitis B virus (HBV) is the main causative agent of HCC in China. The present study aimed to investigate the potential mechanisms underlying HBV-related HCC and to identify core biomarkers by integrated bioinformatics analyses.

Methods

In the present study, HBV-related HCC GSE19665, GSE55092, GSE94660 and GSE121248 expression profiles were downloaded from the Gene Expression Omnibus database. These databases contain data for 299 samples, including 145 HBV-related HCC tissues and 154 non-cancerous tissues (from patients with chronic hepatitis B). The differentially expressed genes (DEGs) from each dataset were integrated and an

SUBMITTER: Xie S 

PROVIDER: S-EPMC6677124 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature