Ontology highlight
ABSTRACT:
SUBMITTER: Yin J
PROVIDER: S-EPMC6677544 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Yin Junxiang J Han Pengcheng P Song Melissa M Nielsen Megan M Beach Thomas G TG Serrano Geidy E GE Liang Winnie S WS Caselli Richard J RJ Shi Jiong J
Molecular neurobiology 20180324 11
Increasing evidence indicates that sirtuin 3 (Sirt3) has neuroprotective effects in regulating oxidative stress and energy metabolism, both of which are involved in the pathogenesis of Alzheimer's disease (AD). However, it is unclear whether Sirt3 is associated with cognitive performance and pathological changes in AD. We conducted a case-control study of the postmortem brains of AD (n = 16), mild cognitive impairment (n = 13), and age- and education-matched cognitively normal (CN, n = 11) subje ...[more]