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DNA fragility in the parallel evolution of pelvic reduction in stickleback fish.


ABSTRACT: Evolution generates a remarkable breadth of living forms, but many traits evolve repeatedly, by mechanisms that are still poorly understood. A classic example of repeated evolution is the loss of pelvic hindfins in stickleback fish (Gasterosteus aculeatus). Repeated pelvic loss maps to recurrent deletions of a pelvic enhancer of the Pitx1 gene. Here, we identify molecular features contributing to these recurrent deletions. Pitx1 enhancer sequences form alternative DNA structures in vitro and increase double-strand breaks and deletions in vivo. Enhancer mutability depends on DNA replication direction and is caused by TG-dinucleotide repeats. Modeling shows that elevated mutation rates can influence evolution under demographic conditions relevant for sticklebacks and humans. DNA fragility may thus help explain why the same loci are often used repeatedly during parallel adaptive evolution.

SUBMITTER: Xie KT 

PROVIDER: S-EPMC6677656 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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DNA fragility in the parallel evolution of pelvic reduction in stickleback fish.

Xie Kathleen T KT   Wang Guliang G   Thompson Abbey C AC   Wucherpfennig Julia I JI   Reimchen Thomas E TE   MacColl Andrew D C ADC   Schluter Dolph D   Bell Michael A MA   Vasquez Karen M KM   Kingsley David M DM  

Science (New York, N.Y.) 20190103 6422


Evolution generates a remarkable breadth of living forms, but many traits evolve repeatedly, by mechanisms that are still poorly understood. A classic example of repeated evolution is the loss of pelvic hindfins in stickleback fish (<i>Gasterosteus aculeatus</i>). Repeated pelvic loss maps to recurrent deletions of a pelvic enhancer of the <i>Pitx1</i> gene. Here, we identify molecular features contributing to these recurrent deletions. <i>Pitx1</i> enhancer sequences form alternative DNA struct  ...[more]

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