Dataset Information

Novel metabolic indices and incident type 2 diabetes among women and men: the Rotterdam Study.

ABSTRACT:

Aims/hypothesis

Both visceral and truncal fat have been associated with metabolic disturbances. We aimed to investigate the associations of several novel metabolic indices, combining anthropometric and lipid measures, and dual-energy x-ray absorptiometry (DXA) measurements of body fat, with incident type 2 diabetes among women and men from the large population-based Rotterdam Study.

Methods

Cox proportional hazards models were used to investigate associations of visceral adiposity index (VAI), lipid accumulation product (LAP), the product of triacylglycerol and glucose (TyG), their formula components and DXA measures with incident type 2 diabetes. Associations were adjusted for traditional diabetes risk factors.

Results

Among 5576 women and 3988 men free of diabetes, 511 women and 388 men developed type 2 diabetes during a median follow-up of 6.5 years. In adjusted models, the three metabolic indices VAI (per 1 SD naturally log-transformed HR; 95% CI) (1.49; 1.36, 1.65 in women; 1.37; 1.22, 1.53 in men), LAP (1.35; 1.16, 1.56 in women; 1.19; 1.01, 1.42 in men) and TyG (1.73; 1.52, 1.98 in women; 1.43; 1.26, 1.62 in men), gynoid fat mass (0.63; 0.45, 0.89) and android to gynoid fat ratio (1.51; 1.16, 1.97) in women were associated with incident type 2 diabetes. BMI (1.45; 1.28, 1.65) was the strongest predictor of type 2 diabetes in men.

Conclusions/interpretation

Among women, novel combined metabolic indices were stronger risk markers for type 2 diabetes than the traditional anthropometric and laboratory measures and were comparable with DXA measures. Neither combined metabolic indices nor DXA measures were superior to traditional anthropometric and lipid measures in association with type 2 diabetes among men.

SUBMITTER: Brahimaj A

PROVIDER: S-EPMC6677703 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Publications

Novel metabolic indices and incident type 2 diabetes among women and men: the Rotterdam Study.

Brahimaj Adela A Rivadeneira Fernando F Muka Taulant T Sijbrands Eric J G EJG Franco Oscar H OH Dehghan Abbas A Kavousi Maryam M

Diabetologia 20190610 9

<h4>Aims/hypothesis</h4>Both visceral and truncal fat have been associated with metabolic disturbances. We aimed to investigate the associations of several novel metabolic indices, combining anthropometric and lipid measures, and dual-energy x-ray absorptiometry (DXA) measurements of body fat, with incident type 2 diabetes among women and men from the large population-based Rotterdam Study.<h4>Methods</h4>Cox proportional hazards models were used to investigate associations of visceral adiposity ...[more]

PMID: 31183505

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Dataset Information

Novel metabolic indices and incident type 2 diabetes among women and men: the Rotterdam Study.

Aims/hypothesis

Methods

Results

Conclusions/interpretation

Publications

Novel metabolic indices and incident type 2 diabetes among women and men: the Rotterdam Study.

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