Ontology highlight
ABSTRACT:
SUBMITTER: van der Lee SJ
PROVIDER: S-EPMC6677735 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
van der Lee Sven J SJ Knol Maria J MJ Chauhan Ganesh G Satizabal Claudia L CL Smith Albert Vernon AV Hofer Edith E Bis Joshua C JC Hibar Derrek P DP Hilal Saima S van den Akker Erik B EB Arfanakis Konstantinos K Bernard Manon M Yanek Lisa R LR Amin Najaf N Crivello Fabrice F Cheung Josh W JW Harris Tamara B TB Saba Yasaman Y Lopez Oscar L OL Li Shuo S van der Grond Jeroen J Yu Lei L Paus Tomas T Roshchupkin Gennady V GV Amouyel Philippe P Jahanshad Neda N Taylor Kent D KD Yang Qiong Q Mathias Rasika A RA Boehringer Stefan S Mazoyer Bernard B Rice Ken K Cheng Ching Yu CY Maillard Pauline P van Heemst Diana D Wong Tien Yin TY Niessen Wiro J WJ Beiser Alexa S AS Beekman Marian M Zhao Wanting W Nyquist Paul A PA Chen Christopher C Launer Lenore J LJ Psaty Bruce M BM Ikram M Kamran MK Vernooij Meike W MW Schmidt Helena H Pausova Zdenka Z Becker Diane M DM De Jager Philip L PL Thompson Paul M PM van Duijn Cornelia M CM Bennett David A DA Slagboom P Eline PE Schmidt Reinhold R Longstreth W T WT Ikram M Arfan MA Seshadri Sudha S Debette Stéphanie S Gudnason Vilmundur V Adams Hieab H H HHH DeCarli Charles C
Communications biology 20190802
Brain lobar volumes are heritable but genetic studies are limited. We performed genome-wide association studies of frontal, occipital, parietal and temporal lobe volumes in 16,016 individuals, and replicated our findings in 8,789 individuals. We identified six genetic loci associated with specific lobar volumes independent of intracranial volume. Two loci, associated with occipital (6q22.32) and temporal lobe volume (12q14.3), were previously reported to associate with intracranial and hippocamp ...[more]