A human memory circuit derived from brain lesions causing amnesia.
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ABSTRACT:
SUBMITTER: Ferguson MA
PROVIDER: S-EPMC6677746 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
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A human memory circuit derived from brain lesions causing amnesia.
Ferguson Michael A MA Lim Chun C Cooke Danielle D Darby R Ryan RR Wu Ona O Rost Natalia S NS Corbetta Maurizio M Grafman Jordan J Fox Michael D MD
Nature communications 20190802 1
Human memory is thought to depend on a circuit of connected brain regions, but this hypothesis has not been directly tested. We derive a human memory circuit using 53 case reports of strokes causing amnesia and a map of the human connectome (n = 1000). This circuit is reproducible across discovery (n = 27) and replication (n = 26) cohorts and specific to lesions causing amnesia. Its hub is at the junction of the presubiculum and retrosplenial cortex. Connectivity with this single location define ...[more]
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