Ontology highlight
ABSTRACT:
SUBMITTER: Ren J
PROVIDER: S-EPMC6677920 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Ren Jingshan J Nettleship Joanne E JE Harris Gemma G Mwangi William W Rhaman Nahid N Grant Clare C Kotecha Abhay A Fry Elizabeth E Charleston Bryan B Stuart David I DI Hammond John J Owens Raymond J RJ
Molecular immunology 20190514
Cattle antibodies have unusually long CDR3 loops in their heavy chains (HCs), and limited light chain (LC) diversity, raising the question of whether these mask the effect of LC variation on antigen recognition. We have investigated the role of the LC in the structure and activity of two neutralizing cattle antibodies (B4 and B13) that bind the F protein of bovine respiratory syncytial virus (bRSV). Recombinant Fab fragments of B4 and B13 bound bRSV infected cells and showed similar affinities f ...[more]