Mitophagy in Parkinson's Disease: From Pathogenesis to Treatment.
Ontology highlight
ABSTRACT:
SUBMITTER: Liu J
PROVIDER: S-EPMC6678174 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Publications
Mitophagy in Parkinson's Disease: From Pathogenesis to Treatment.
Liu Jia J Liu Weijin W Li Ruolin R Yang Hui H
Cells 20190712 7
Parkinson's disease (PD) is the second most common neurodegenerative disease. The pathogenesis of PD is complicated and remains obscure, but growing evidence suggests the involvement of mitochondrial and lysosomal dysfunction. Mitophagy, the process of removing damaged mitochondria, is compromised in PD patients and models, and was found to be associated with accelerated neurodegeneration. Several PD-related proteins are known to participate in the regulation of mitophagy, including PINK1 and Pa ...[more]
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