Ontology highlight
ABSTRACT:
SUBMITTER: Hirose M
PROVIDER: S-EPMC6678443 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Hirose Misa M Schilf Paul P Zarse Kim K Busch Hauke H Fuellen Georg G Jöhren Olaf O Köhling Rüdiger R König Inke R IR Richer Barbara B Rupp Jan J Schwaninger Markus M Seeger Karsten K Sina Christian C Ristow Michael M Ibrahim Saleh M SM
Genes 20190713 7
Mitochondrial complex I-the largest enzyme complex of the mitochondrial oxidative phosphorylation machinery-has been proposed to contribute to a variety of age-related pathological alterations as well as longevity. The enzyme complex-consisting proteins are encoded by both nuclear (nDNA) and mitochondrial DNA (mtDNA). While some association studies of mtDNA encoded complex I genes and lifespan in humans have been reported, experimental evidence and the functional consequence of such variants is ...[more]