Ontology highlight
ABSTRACT:
SUBMITTER: Van Acker HH
PROVIDER: S-EPMC6678613 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Van Acker Heleen H HH Van Acker Zoë P ZP Versteven Maarten M Ponsaerts Peter P Pende Daniela D Berneman Zwi N ZN Anguille Sébastien S Van Tendeloo Viggo F VF Smits Evelien L EL
Cancers 20190722 7
A particularly interesting marker to identify anti-tumor immune cells is the neural cell adhesion molecule (NCAM), also known as cluster of differentiation (CD)56. Namely, hematopoietic expression of CD56 seems to be confined to powerful effector immune cells. Here, we sought to elucidate its role on various killer immune cells. First, we identified the high motility NCAM-120 molecule to be the main isoform expressed by immune cells. Next, through neutralization of surface CD56, we were able to ...[more]