Ontology highlight
ABSTRACT:
SUBMITTER: Bellocchi MC
PROVIDER: S-EPMC6678654 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Bellocchi Maria Concetta MC Aragri Marianna M Carioti Luca L Fabeni Lavinia L Pipitone Rosaria Maria RM Brancaccio Giuseppina G Sorbo Maria Chiara MC Barbaliscia Silvia S Di Maio Velia Chiara VC Bronte Fabrizio F Grimaudo Stefania S Mazzucco Walter W Frigeri Ferdinando F Cantone Marco M Pinto Antonio A Pinto Antonio A Perno Carlo Federico CF Craxì Antonio A Gaeta Giovanni Battista GB Di Marco Vito V Ceccherini-Silberstein Francesca F
Cells 20190702 7
<b>Background</b>: The aim of the study was to investigate the intra-host variability through next-generation-sequencing (NGS) of the NS5A-gene in nosocomial transmission-clusters observed in two Italian hospitals among hepatitis C virus (HCV)-genotype-1b infected patients. <b>Methods</b>: HCV-sequencing was performed by Sanger-sequencing (NS3 + NS5A + NS5B) and by NGS (NS5A, MiSeq-Illumina) in 15 HCV-1b infected patients [five acute with onco-hematologic-disease and 10 (4/6 acute/chronic) with ...[more]